南海的形成与演变

南海是东亚陆缘最大的边缘海，构造类型多样，油气资源丰富。然而，科学家们对于南海如何发育演化成今天的局面、深部的驱动机制以及影响因素尚存在诸多争议。为解决上述问题，科学家在南海开展了大量的地球物理调查以及三轮五次的国际大洋钻探，取得重要进展。文章综合多年来的研究和认识，对南海的成因归属和发育演化历史进行了总结。在此基础上提出尚存在的三个前沿科学问题，包括南海主-被动陆缘转换的机制、南海陆缘破裂方式、南海存在大量岩浆活动的机制等，希望能通过更多深探测手段和更多的大洋钻探去揭示这些问题，从而服务南海的资源开发和灾害预警。     

具有迁移效应和隔离措施的COVID-19传播模型分析

基于COVID-19传播过程中人口流动的必然性、无症状感染者的普遍性和隔离策略的有效性,该文提出了一类具有迁移效应、无症状感染者、自我防护意识和隔离策略的COVID-19传播动力学模型,利用下一代矩阵方法给出了各类子系统和全系统基本再生数的精确表达式.进一步地,通过采用线性近似理论,构造Lyapunov函数、比较原理等方法,得到了无病平衡点的全局渐近稳定性以及疾病的持久性.最后,数值模拟解释了主要的理论结果以及人口的迁移和隔离对疾病传播的影响.     

石杉碱甲片联合丁苯酞软胶囊对轻度阿尔茨海默病患者认知功能的疗效观察

目的 评价石杉碱甲片联合丁苯酞软胶囊对阿尔茨海默病患者认知功能的临床疗效.方法 将100例轻度阿尔茨海默病(Alzheimer's disease,AD)患者随机分为石杉碱甲片联合丁苯酞软胶囊组(治疗组)及单独应用石杉碱甲组(对照组).治疗前及治疗90 d后分别评价两组患者简易智力状态检查(Mini-mental State Examination,MMSE)量表、事件诱发电位P300潜伏期、波幅及不良反应.结果 石杉碱甲片联合丁苯酞软胶囊组治疗90 d后,MMSE评分和P300潜伏期、波幅与治疗前比较差异均具有统计学意义(P<0.05);与单独应用石杉碱甲组比较差异具有统计学意义(P<0.05).结论 石杉碱甲片联合丁苯酞软胶囊对轻度阿尔茨海默病患者认知功能有明显改善,且优于单独应用石杉碱甲片组.     

Evolutionary game analysis of low-carbon behavior credit supervision of logistics enterprises

Based on the low-carbon obligation fulfillment of Chinese logistics enterprises, this study constructs a tripartite evolutionary game model to analyze the evolutionary process of the interaction between the local government, logistics enterprises and the public in the process of low-carbon behavior credit supervision. Then using Netlogo software, a parameter simulation experiment is conducted to determine the optimal policy for improving the effect of supervision. The results are as follows: ① The combined influence of the local government and the public can effectively change the strategic choice of enterprises and promote the low-carbon behavior of enterprises. ② In terms of improving the effect of supervision, reducing the cost of government supervision would have a highly significant effect, and reducing the cost of the public would be counterproductive. ③ Increasing the government subsidies to enterprises and the government’s fines to enterprises both have a significant effect, and the effect of improving the former is better. However, increasing the severity of higher-level governments punishing local governments will reduce the stability of the system. ④ Supervision can be more effective by increasing the public’s impact on enterprises’ earnings rather than by increasing government subsidies to the public.     

基于动态博弈的补贴模式对机场群航线网络结构的影响研究

为探讨不同补贴模式对机场群航线网络结构的影响，本文构建了关于机场、航空公司和乘客之间的动态博弈模型，通过逆向归纳法得到了纳什均衡条件. 研究结果发现：（1）不同的补贴模式对多机场航线网络结构产生重要影响，低补贴模式促使机场群倾向于形成点对点航线网络结构，反之，在高补贴模式下机场群易于形成枢纽辐射航线网络； （2）在较低的空铁联运总运营成本环境下，补贴竞争使得航空公司倾向于选择系统内的大型机场作为枢纽机场；反之，如果空铁联运总运营成本相对较高，补贴竞争使得航空公司倾向于选择小机场作为枢纽节点； （3）随航班固定成本和空铁联运总运营成本的增大，大型机场作为枢纽节点的概率逐渐减少，而小机场被选为枢纽节点的概率将逐渐增大. 随着机场群内大型机场腹地服务人口比例的增大，航空公司选择点对点航线网络的概率在减小. 研究结论能够为民航管理部门科学制定和应用航线补贴政策提供决策依据.     

Improving the photocatalytic activity of graphitic carbon nitride by thermal treatment in a high-pressure hydrogen atmosphere

Extending visible light absorption range and suppressing the recombination of photogenerated charge carriers are always important topics in developing efficient solar-driven photocatalysts. In this study, the thermal treatment process at 400 °C in a high-pressure hydrogen atmosphere was applied to modify graphitic carbon nitride. Compared to the normal atmospheric hydrogen treatment process, this process has the merit of producing nitrogen deficient graphitic carbon nitride in high-yield. The optimal photocatalytic activity of modified graphitic carbon nitride was demonstrated by controlling the treatment duration in the hydrogen atmosphere.The changes in the crystal structure, microstructure and optical properties of carbon nitrides were investigated by several characterizations. The relationship between the photocatalytic activity and structures of graphitic carbon nitride was preliminarily established. The results obtained in this study could provide some new ways of improving the activity of graphitic carbon nitride based photocatalyst.     

Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets

Introduction

Islets synthesise and secrete numerous peptides, some of which are known to be important regulators of islet function and glucose homeostasis. In this study, we quantified mRNAs encoding all peptide ligands of islet G protein-coupled receptors (GPCRs) in isolated human and mouse islets and carried out in vitro islet hormone secretion studies to provide functional confirmation for the species-specific role of peptide YY (PYY) in mouse islets.

Materials and methods

GPCR peptide ligand mRNAs in human and mouse islets were quantified by quantitative real-time PCR relative to the reference genes ACTB, GAPDH, PPIA, TBP and TFRC. The pathways connecting GPCR peptide ligands with their receptors were identified by manual searches in the PubMed, IUPHAR and Ingenuity databases. Distribution of PYY protein in mouse and human islets was determined by immunohistochemistry. Insulin, glucagon and somatostatin secretion from islets was measured by radioimmunoassay.

Results

We have quantified GPCR peptide ligand mRNA expression in human and mouse islets and created specific signalomes mapping the pathways by which islet peptide ligands regulate human and mouse GPCR signalling. We also identified species-specific islet expression of several GPCR ligands. In particular, PYY mRNA levels were ~ 40,000-fold higher in mouse than human islets, suggesting a more important role of locally secreted Pyy in mouse islets. This was confirmed by IHC and functional experiments measuring insulin, glucagon and somatostatin secretion.

Discussion

The detailed human and mouse islet GPCR peptide ligand atlases will allow accurate translation of mouse islet functional studies for the identification of GPCR/peptide signalling pathways relevant for human physiology, which may lead to novel treatment modalities of diabetes and metabolic disease.

     

Uncoupled PID Control of Coupled Multi-Agent Nonlinear Uncertain systems

In this paper, PID (proportional-integral-derivative) controllers will be designed to solve the tracking problem for a class of coupled multi-agent systems, where each agent is described by a second-order high-dimensional nonlinear uncertain dynamical system, which only has access to its own tracking error information and does not need to communicate with others. This paper will show that a 3-dimensional manifold can be constructed based on the information about the Lipschitz constants of the system nonlinear dynamics, such that whenever the three parameters of each PID controller are chosen from the manifold, the whole multi-agent system can be stabilized globally and the tracking error of each agent approaches to zero asymptotically. For a class of coupled first-order multi-agent nonlinear uncertain systems, a PI controller will be designed to stabilize the whole system.     

A Novel Routing Method for Social Delay-Tolerant Networks

The lack of continuous connectivity and a complete path from source to destination makes node communication quite difficult in Delay-Tolerant Networks(DTNs). Most studies focus on routing problems in idealized network environments without considering social properties. Communication devices are carried by individuals in many DTNs; therefore, DTNs are unique social networks to some extent. To design efficient routing protocols for DTNs, it is important to analyze their social properties. In this paper, a more accurate and comprehensive metric for detecting the quality of the relationships between nodes is proposed, by considering the contact time, contact frequency, and contact regularity. An overlapping hierarchical community detection method is designed based on this new metric, and a tree structure is built. Furthermore, we exploit the overlapping community structure and the tree structure to provide message-forwarding paths from the source node to the destination node.The simulation results show that our Routing method based on Overlapping hierarchical Community Detection(ROCD) achieves better delivery rate than SimBet and Bubble Rap, the classic routing protocols, without affecting the average delay.     

循环作用对马蹄寺石窟群岩体性能的影响

马蹄寺石窟群地处河西走廊中部,气候条件十分恶劣。由于常年受到温度、湿度、酸碱盐等作用的影响,石窟岩体性能出现了不同程度的劣化现象。通过开展室内模拟试验,研究以上多种恶劣环境的循环作用对于岩体抗压强度、波速、质量的影响规律,同时使用X射线衍射仪(X-ray diffraction,XRD)、X射线荧光光谱(X-ray fluorescence,XRF)和扫描电子显微镜(scanning electron microscope,SEM)对循环作用过程中样品的矿物组分、元素含量和微观形貌进行分析研究。研究结果表明,循环作用使样品中的长石类矿物和方解石含量降低,黏土类矿物含量增加,胶结程度下降,孔隙逐渐发展成为横向微裂隙,导致样品的性能出现不同程度的劣化现象。循环作用对岩体性能的影响程度从大到小依次为冻融循环、耐盐循环、耐碱循环、耐酸循环和温湿循环。